Research progress in pathogenesis and preventive measures of human immunodeficiency virus-related osteoporotic fragility fracture / 中华创伤杂志

ABSTRACT

Human immunodeficiency virus (HIV), known as acquired immune deficiency syndrome virus, is characterized by immune function deficiency or loss due to the destruction of the human immune system, thereby causing opportunistic infection and other serious complications with extremely high fatality. As a result of the widespread application of antiretroviral therapy (ART) in recent years, the life expectancy of HIV-positive patients is approaching that of the general population. However, the adverse effects of HIV, ART and immune system changes to bone metabolism are becoming increasingly prominent. The risk of osteoporotic fragility fracture among HIV-positive patients is significantly higher than that of the general population. The authors review the research progress in HIV-related osteoporotic fragility fracture from aspects of epidemiological characteristics, possible pathogenesis and preventive measures so as to provide references for clinical diagnosis and treatment.