Programmed death-1/programmed death ligand-1 signaling pathway in idiopathic inflammatory myopathies / 中华皮肤科杂志
Chinese Journal of Dermatology
;
(12): 633-636, 2022.
Artículo
en Chino
| WPRIM
| ID: wpr-957708
ABSTRACT
After the specific binding of programmed death-1 (PD-1) to programmed death ligand 1 (PD-L1) , the PD-1/PD-L1 complex can exert a co-suppressive/co-stimulatory immunoregulatory effect, which can inhibit the activation and proliferation of T cells and their cytokine secretion, and play a key role in tumor immunity, autoimmunity and immune tolerance. This review summarizes structures and regulatory mechanisms of the PD-1/PD-L1 signaling pathway, aimming to facilitate the understanding of immune pathogenesis of idiopathic inflammatory myopathies complicated by malignant tumors, and to seek potential therapeutic targets and diagnostic strategies.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Chinese Journal of Dermatology
Año:
2022
Tipo del documento:
Artículo
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