Apo-1/Fas (CD95) Gene Polymorphism in Korean Knee Osteoarthritis Patients
Immune Network
;
: 145-149, 2003.
Artículo
en Coreano
| WPRIM
| ID: wpr-9579
ABSTRACT
BACKGROUND:
Apoptosis has been implicated in pathogenesis of various disease. Apo-1/Fas (CD95) is one of the main pathway of apoptosis. To examine the possible relationship between Apo-1/Fas (CD95) and primary knee osteoarthritis, MvaI restriction length polymorphism (RFLP) in human Apo-1/Fas (CD95) gene was assessed.METHODS:
Genotype and allele frequencies in promoter region in the Apo-1/Fas (CD95) gene were studied by PCR-RFLP in 226 Korean controls and 148 Korean patients with primary knee osteoarthritis.RESULTS:
No statistically significant difference in the genotypic distribution and allelic frequencies was found between the control and the knee oateoarthritis patients. But in the severe grade (grade 3, 4) Kellgren-Lawrence score patients, the frequency of MvaI*1 (G) allele was significantly decreased (P=0.0392) and the of MvaI*2 (A) allele frequency was significantly increased (P=0.0473) compared to the normal controls.CONCLUSION:
Apo-1/Fas (CD95) gene polymorphism is a part a determinant factor of severity in knee osteoarthritis, the patients with MvaI*2 (A) allele is more severe radiologic progression. Further substantiation studies are needed in larger patient samples and various other apoptosis related genes to elucidate the mechanism of osteoarthritis, including the Fas ligand gene analysis.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Osteoartritis
/
Regiones Promotoras Genéticas
/
Apoptosis
/
Osteoartritis de la Rodilla
/
Alelos
/
Proteína Ligando Fas
/
Frecuencia de los Genes
/
Genotipo
/
Rodilla
Límite:
Humanos
Idioma:
Coreano
Revista:
Immune Network
Año:
2003
Tipo del documento:
Artículo
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