Association between γ-Aminobutyric Acid B2 Receptor Gene Polymorphism rs3750344 and Bone Mass Content or Bone Mass Density in Chinese Hans Population / 中国康复理论与实践

ABSTRACT

@# ObjectiveTo investigate the association of γ-aminobutyric acid B2 receptor (GABABR2) gene polymorphism rs3750344 and bone mass (bone mass content, BMC, and bone mass density, BMD) in population of Chinese Hans lives in Jinan. Methods425 volunteers were recruited. BMC and BMD of all subjects were measured with dual energy X-ray absorptiometry (DXA). Genotyping of polymorphism rs3750344 was conducted using Taqman assays. ResultsBMD and BMC increased with the copy of the C allele of rs3750344 in whole body. ConclusionThe C allele of GABABR2 rs3750344 increases the levers of BMD and BMC in Chinese Han population.