The clinicopathological relevance of Poly (ADP-ribose) polymerase (PARP) expression in epithelial ovarian cancer / 대한산부인과학회지

ABSTRACT

OBJECTIVE: To evaluate the clinicopathological implication of poly (ADP-ribose) polymerase (PARP) expression in epithelial ovarian cancer. METHODS: Retrospectively, slide samples (n=72) were analyzed. PARP expression was analyzed using immunohistochemical staining. RESULTS: Of 72 cases, positive PARP expression were 27 cases (37.5%). PARP expression showed negative correlation with FIGO stage (p=0.004) and mitotic count (p=0.010), but showed no correlation with grade (p=0.053), tumor size (p=0.301), Ki-67 LIs (p=0.986), p53 positivity (p=0.414), and bcl-2 positivity (p=0.413). CONCLUSION: PARP expression showed negative correlation with advanced stage and mitoses in epithelial ovarian cancer. Therefore PARP expression could be a new prognostic factor in epithelial ovarian cancer.