Cerebral salt-wasting syndrome after hematopoietic stem cell transplantation in adolescents: 3 case reports
Annals of Pediatric Endocrinology & Metabolism
;
: 220-225, 2015.
Artículo
en Inglés
| WPRIM
| ID: wpr-96137
ABSTRACT
Cerebral salt-wasting syndrome (CSWS) is a rare disease characterized by a extracellular volume depletion and hyponatremia induced by marked natriuresis. It is mainly reported in patients who experience a central nervous system insult, such as cerebral hemorrhage or encephalitis. The syndrome of inappropriate antidiuretic hormone secretion is a main cause of severe hyponatremia after hematopoietic stem cell transplantation, whereas CSWS is rarely reported. We report 3 patients with childhood acute leukemia who developed CSWS with central nervous system complication after hematopoietic stem cell transplantation. The diagnosis of CSW was made on the basis of severe hyponatremia accompanied by increased urine output with clinical signs of dehydration. All patients showed elevated natriuretic peptide and normal antidiuretic hormone. Aggressive water and sodium replacement treatment was instituted in all 3 patients and 2 of them were effectively recovered, the other one was required to add fludrocortisone administration.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Poliuria
/
Sodio
/
Fludrocortisona
/
Células Madre Hematopoyéticas
/
Agua
/
Leucemia
/
Sistema Nervioso Central
/
Hemorragia Cerebral
/
Trasplante de Células Madre Hematopoyéticas
/
Deshidratación
Tipo de estudio:
Estudio diagnóstico
Límite:
Humanos
Idioma:
Inglés
Revista:
Annals of Pediatric Endocrinology & Metabolism
Año:
2015
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS