A case of acute drug-induced hepatotoxicity after albendazole treatment / 대한내과학회지
Korean Journal of Medicine
;
: 564-568, 2008.
Artículo
en Coreano
| WPRIM
| ID: wpr-9622
ABSTRACT
Drug-induced hepatotoxicity is injury to the liver as a result of drug exposure. Due to their unpredictable nature, drug-induced liver injuries pose a serious problem for clinicians, health agencies, and pharmaceutical firms. Albendazole is a benzimidazole with wide spectrum coverage as an antiparasitic drug. Very few cases of high-dose albendazole-induced hepatotoxicity have been reported so far, and no case in response to a single dose. A 25-year-old man presented to our hospital with dark urine. Twenty days prior to presentation, he took a tablet of albendazole (400 mg) as a prophylactic treatment for lumbricosis. Upon laboratory analysis, aspartate aminotransferase (AST) was 748 IU/L, alanine transaminase (ALT) was 939 IU/L, and total/direct bilirubin was 9.3/7.3 mg/dL. The patient was negative for viral markers (HAV, HBV, and HCV) and autoantibodies. Abdominal ultrasonography revealed no evidence of chronic liver damage. The pathology was compatible with drug-induced hepatotoxicity. The patient improved with conservative management only.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Aspartato Aminotransferasas
/
Autoanticuerpos
/
Bencimidazoles
/
Bilirrubina
/
Biomarcadores
/
Albendazol
/
Alanina Transaminasa
/
Enfermedad Hepática Inducida por Sustancias y Drogas
/
Hígado
Límite:
Adulto
/
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Medicine
Año:
2008
Tipo del documento:
Artículo
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