Prevalence of occult HBV infection in alcholic and non-alcoholic subjects lacking the hepatitis B surface antigen / 대한내과학회지
Korean Journal of Medicine
;
: 539-545, 2008.
Artículo
en Coreano
| WPRIM
| ID: wpr-9626
ABSTRACT
BACKGROUNDS/AIMS:
Hepatitis B virus (HBV) infection and chronic alcoholism are major risk factors for chronic liver disease in Korea.METHODS:
We investigated the prevalence of occult HBV infection in 198 non-alcoholic (group I) and 85 chronic alcoholic subjects (group II), none of whom showed the hepatitis B surface antigen (HBsAg). Among chronic alcoholics, 25 patients showed cirrhosis. Using serum samples stored at -70 degrees C, liver enzymes, anti-Hbs, and IgG anti-HBc were measured via EIA and serum HBV DNA was quantified via real time PCR.RESULTS:
IgG anti-HBc seropositivity, an indicator of past infection, was higher in group II (64.7%) than in group I (43.4%; p<0.01). Eleven of 283 patients (3.2%) were seropositive for HBV DNA, indicating occult infection, but this value did not differ between groups (group I 3.5%, 7/198; group II 4.7%, 4/85; p=0.64). In group II, HBV DNA seropositivity was higher in cirrhotic patients (12%, 3/25) than in non-cirrhotic alcoholic liver disease (1.7%, 1/60; p=0.074).CONCLUSIONS:
Past HBV infection was more prevalent in alcoholics than non-alcoholics, but the prevalence of occult HBV infection did not differ between groups. However, alcoholics with cirrhosis tended to show a higher prevalence of occult HBV infection.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Fibrosis
/
ADN
/
Inmunoglobulina G
/
Virus de la Hepatitis B
/
Prevalencia
/
Factores de Riesgo
/
Alcoholismo
/
Alcohólicos
/
Reacción en Cadena en Tiempo Real de la Polimerasa
/
Hepatitis
Tipo de estudio:
Estudio de etiología
/
Estudio de prevalencia
/
Factores de riesgo
Límite:
Humanos
País/Región como asunto:
Asia
Idioma:
Coreano
Revista:
Korean Journal of Medicine
Año:
2008
Tipo del documento:
Artículo
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