Effects of intraperitoneal injections of "Tungog" in white sprague rats-inquiry on "Tungog" (an additive of tuba)

ABSTRACT

A 30-minutes infusion of "tungog" in normal saline was injected intraperitoneally to 59 white Sprague rats. Marked clinical and anatomic changes developed in animals which received 10 to 20 serial injections of 0.5 cc of the infusion 1 to 2 times a week plus a single additional dose of 0.75 cc per 100-gram body weight. The liver and spleen were contracted and deformed in more than 50% of the subjects. The hepatic cells showed varying degrees of hyaline and feathery degeneration which sometimes proceeded to necrosis. Concomitantly, there was secondary regenerating hyperplasia often to a marked degree. The changes in the spleen were described. (Author)