Trial with clostridium tetani toxoid in the inhibition of malaria relapse

ABSTRACT

The effect of injection of one cc. Clostridium tetani toxoid, one week after a clinical cure of malaria, and repeated after three weeks, was tried on patients who had contracted malaria elsewhere in the Philippines, but who had settled in Manila ( non-endemic area.) Observation was carried on until the first appearance of relapse for a period of one year for each case. The percentage of relapse in the experimental groups did not vary from those of the corresponding control groups. The results show that Clostridium tetani toxoid does not exert any anti-relapse activity in malaria, contrary to the claim of Dr. E.Y. Garcia.(Summary)