Field studies on the treatment of schistosomiasis japonica with nilodin

ABSTRACT

Nilodin was tried in 238 cases of Schistosomiasis japonica, most of whom were early cases; but only in 233 was the treatment completedThe total dosage given per treatment was 60 mgm. per kilo body weight, administered by mouth in divided doses for a period of three to six days, proportionately reduced in children according to weight. That an adult of 50 kg. received a total of three Gm. or one Gm. a day for period of three days or 0.5 Gm. a day to six daysThe results showed that, of the 233 who completed the treatment 218 or 93.24% were still positive for viable eggs from one to four weeks after the treatment; only 13 or 5.40% became negativeToxic reactions, which were usually too mild and insufficient stop treatment, occurred in 229, or 96.6%, of the casesJudging from the results of this study, it would seem that Nilodin is not effective in the treatment of Schistosoma japonicum, with the same dosage used against S. mansoni and S. baematobium infections. It is hoped, however, that further studies on this treatment, with increased dosage, will be made. (Summary)