Research progress on biomarkers for pneumoconiosis / 中国职业医学

ABSTRACT

@#Abstract - Well characteristic biomarkers are helpful for understanding the disease condition of patients with occupational pneumoconiosisand predictthediseaseevolution.Currently,related biomarkersarewidelystudied and theyincludeepithelial cell injury related biomarkers such as salivary glycochain antigen, Clara cell protein and surfactant protein; inflammatory - - response related biomarkers such as interleukin, tumor necrosis factor α, chemokine, high mobility group protein 1 and - - L selectin; oxidative stress related biomarkers such as superoxide dismutase, glutathione, malondialdehyde, heme oxygenase 1 and lactate dehydrogenase; pulmonary fibrosis related biomarkers such as matrix metalloproteinases and transforming growth - - - - - factor β; non coding RNA such as miR 19a, miR 29 and miR 146a, et al. These biomarkers are helpful to understand the pathogenesisofoccupationalpneumoconiosisandguidethediagnosis,treatmentandprognosis.However,moreresearchneedsto-bedoneontherepeatabilitytestofbiomarkers,combinedapplicationandtheminingofnoncodingRNAastargetsfordisease diagnosisandtreatment.