Delayed allograft rejection by the suppression of class II transactivator
Experimental & Molecular Medicine
;
: 210-216, 2006.
Artículo
en Inglés
| WPRIM
| ID: wpr-96570
ABSTRACT
We examined the effect of class II transactivator (CIITA) down-modulation on allograft rejection. To inhibit the function of CIITA, we constructed a series of CIITA mutants and found one exhibiting the dominant-negative effect on the regulation of major histocompatibility complex (MHC) class II expression. To test whether the CIITA dominant-negative mutant reduces immunogenecity, CIITA-transfected melanoma cells were injected into allogeneic host and assessed for immune evading activity against host immune cells. We demonstrated that the CIITA dominant-negative mutant allowed tumor nodules to develop earlier in the lung than control by this tumor challenge study. Furthermore, skin grafts deficient for CIITA also survived longer than wild-type in allogeneic hosts. Both the tumor challenge and skin graft studies suggest the inhibition of CIITA molecules in donor tissue would be beneficial to the control of allo-response.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Trasplante Homólogo
/
Melanoma Experimental
/
Ratones Transgénicos
/
Proteínas Nucleares
/
Transfección
/
Antígenos de Histocompatibilidad Clase II
/
Activación Transcripcional
/
Transactivadores
/
Interferón gamma
/
Trasplante de Piel
Límite:
Animales
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Experimental & Molecular Medicine
Año:
2006
Tipo del documento:
Artículo
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