New Therapeutic Approaches to the Treatment of Dyslipidemia 2: LDL-C and Lp(a)
Journal of Lipid and Atherosclerosis
;
: 37-46, 2023.
Artículo
en Inglés
| WPRIM
| ID: wpr-967537
ABSTRACT
Dyslipidemia is an important risk factor for atherosclerotic cardiovascular disease (ASCVD).There are abundant and unequivocal data to indicate that low-density lipoproteins (LDL) are a cause of ASCVD. Reduction of plasma low-density lipoprotein cholesterol (LDL-C) by medical therapy such as statins, ezetimibe and proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors have proven to significantly reduce the risk of cardiovascular events. However, for many reasons, many patients are not able to achieve LDL-C levels recommended by guidelines on currently available therapies. This has led to the development of new drugs lowering LDL-C, such as inclisiran, bempedoic acid, and evinacumab, in the hope of reducing cardiovascular (CV) risk. Drugs targeting lipoprotein (a) (Lp[a]) also have a role in the prevention of atherosclerosis, with genetic studies having established that 20%–30% of the human population inherits plasma Lp(a) levels in the atherogenic range.In this paper, we will review the recent progress made in the approaches to LDL-C and Lp(a) therapeutic modulation.
Texto completo:
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Índice:
WPRIM (Pacífico Occidental)
Idioma:
Inglés
Revista:
Journal of Lipid and Atherosclerosis
Año:
2023
Tipo del documento:
Artículo
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