Effect of Morroniside on Cerebral Infarction Volume in Focal Cerebral Ischemia-reperfusion Rats / 中国康复理论与实践
Chinese Journal of Rehabilitation Theory and Practice
;
(12): 913-915, 2009.
Artículo
en Chino
| WPRIM
| ID: wpr-969527
ABSTRACT
@#Objective To observe the effect of morroniside on cerebral infarction volume in focal cerebral ischemia-reperfusion rat model.Methods The animal model was induced by occlusion of middle cerebral artery with suture embolus, ischemia for 30 minutes, and reperfusion for 7 days. The infarction volume was measured by 2,3,5-triphenyltetrazolium chloride(TTC) staining technique.Results Compared with sham operation group, the cerebral infarction volume ratios increased obviously in model group and in the drug-treated(90 mg/kg,270 mg/kg)groups. Compared with model group, the cerebral infarction volume ratios decreased obviously in the morroniside-treated(90 mg/kg,270 mg/kg)group,while the cerebral infarction volume ratios in vitamin E-treated(35 mg/kg)group didn't change.Conclusion Morroniside may decrease the cerebral infarction volume after cerebral ischemia-reperfusion. It possesses protective effect against cerebral ischemia-reperfusion injury.
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Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Chinese Journal of Rehabilitation Theory and Practice
Año:
2009
Tipo del documento:
Artículo
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