Progress in research of risk prediction of non-syndromic oral clefts using genetic information / 中华流行病学杂志
Chinese Journal of Epidemiology
;
(12): 504-510, 2023.
Artículo
en Chino
| WPRIM
| ID: wpr-969935
ABSTRACT
Non-syndromic oral cleft (NSOC), a common birth defect, remains to be a critical public health problem in China. In the context of adjustment of childbearing policy for two times in China and the increase of pregnancy at older childbearing age, NSOC risk prediction will provide evidence for high-risk population identification and prenatal counseling. Genome-wide association study and second generation sequencing have identified multiple loci associated with NSOC, facilitating the development of genetic risk prediction of NSOC. Despite the marked progress, risk prediction models of NSOC still faces multiple challenges. This paper summarizes the recent progress in research of NSOC risk prediction models based on the results of extensive literature retrieval to provide some insights for the model development regarding research design, variable selection, model-build strategy and evaluation methods.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Factores de Riesgo
/
Labio Leporino
/
Fisura del Paladar
/
Predisposición Genética a la Enfermedad
/
Polimorfismo de Nucleótido Simple
/
Estudio de Asociación del Genoma Completo
Límite:
Humanos
Idioma:
Chino
Revista:
Chinese Journal of Epidemiology
Año:
2023
Tipo del documento:
Artículo
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