Therapeutic potential of targeting SIRT1 for the treatment of Alzheimer's disease / 生理学报
Acta Physiologica Sinica
;
(6): 99-107, 2023.
Artículo
en Chino
| WPRIM
| ID: wpr-970110
ABSTRACT
Silent information regulator 1 (SIRT1) is one of the seven mammalian proteins of the sirtuin family of NAD+-dependent deacetylases. SIRT1 plays a pivotal role in neuroprotection and ongoing research has uncovered a mechanism by which SIRT1 may exert a neuroprotective effect on Alzheimer's disease (AD). Growing evidence demonstrates that SIRT1 regulates many pathological processes including amyloid-β precursor protein (APP) processing, neuroinflammation, neurodegeneration, and mitochondrial dysfunction. SIRT1 has recently received enormous attention, and pharmacological or transgenic approaches to activate the sirtuin pathway have shown promising results in the experimental models of AD. In the present review, we delineate the role of SIRT1 in AD from a disease-centered perspective and provides an up-to-date overview of the SIRT1 modulators and their potential as effective therapeutics in AD.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Animales Modificados Genéticamente
/
Precursor de Proteína beta-Amiloide
/
Sirtuinas
/
Sirtuina 1
/
Enfermedad de Alzheimer
Límite:
Animales
/
Humanos
Idioma:
Chino
Revista:
Acta Physiologica Sinica
Año:
2023
Tipo del documento:
Artículo
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