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Microdeletions and vertical transmission of the Y-chromosome azoospermia factor region / 亚洲男科学杂志(英文版)
Asian Journal of Andrology ; (6): 5-12, 2023.
Artículo en Inglés | WPRIM | ID: wpr-970984
ABSTRACT
Spermatogenesis is regulated by several Y chromosome-specific genes located in a specific region of the long arm of the Y chromosome, the azoospermia factor region (AZF). AZF microdeletions are the main structural chromosomal abnormalities that cause male infertility. Assisted reproductive technology (ART) has been used to overcome natural fertilization barriers, allowing infertile couples to have children. However, these techniques increase the risk of vertical transmission of genetic defects. Despite widespread awareness of AZF microdeletions, the occurrence of de novo deletions and overexpression, as well as the expansion of AZF microdeletion vertical transmission, remains unknown. This review summarizes the mechanism of AZF microdeletion and the function of the candidate genes in the AZF region and their corresponding clinical phenotypes. Moreover, vertical transmission cases of AZF microdeletions, the impact of vertical inheritance on male fertility, and the prospective direction of research in this field are also outlined.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Oligospermia / Aberraciones Cromosómicas Sexuales / Estudios Prospectivos / Deleción Cromosómica / Cromosomas Humanos Y / Azoospermia / Síndrome de Sólo Células de Sertoli / Infertilidad Masculina Límite: Humanos / Masculino Idioma: Inglés Revista: Asian Journal of Andrology Año: 2023 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Oligospermia / Aberraciones Cromosómicas Sexuales / Estudios Prospectivos / Deleción Cromosómica / Cromosomas Humanos Y / Azoospermia / Síndrome de Sólo Células de Sertoli / Infertilidad Masculina Límite: Humanos / Masculino Idioma: Inglés Revista: Asian Journal of Andrology Año: 2023 Tipo del documento: Artículo