Research progress on the mechanism of phenotypic transformation of pulmonary artery smooth muscle cells induced by hypoxia / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 750-757, 2023.
Artículo
en Inglés
| WPRIM
| ID: wpr-971092
ABSTRACT
Phenotypic transformation of pulmonary artery smooth muscle cells (PASMCs) is a key factor in pulmonary vascular remodeling. Inhibiting or reversing phenotypic transformation can inhibit pulmonary vascular remodeling and control the progression of hypoxic pulmonary hypertension. Recent studies have shown that hypoxia causes intracellular peroxide metabolism to induce oxidative stress, induces multi-pathway signal transduction, including those related to autophagy, endoplasmic reticulum stress and mitochondrial dysfunction, and also induces non-coding RNA regulation of cell marker protein expression, resulting in PASMCs phenotypic transformation. This article reviews recent research progress on mechanisms of hypoxia-induced phenotypic transformation of PASMCs, which may be helpful for finding targets to inhibit phenotypic transformation and to improve pulmonary vascular remodeling diseases such as hypoxia-induced pulmonary hypertension.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Arteria Pulmonar
/
Hipoxia de la Célula
/
Células Cultivadas
/
Miocitos del Músculo Liso
/
Proliferación Celular
/
Remodelación Vascular
/
Hipertensión Pulmonar
/
Hipoxia
Límite:
Humanos
Idioma:
Inglés
Revista:
Journal of Zhejiang University. Medical sciences
Año:
2023
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS