Recent Progress of Nano-drug Combined with Chimeric Antigen Receptor T Cell
Therapy in the Treatment of Soild Tumors / 中国肺癌杂志
Chinese Journal of Lung Cancer
;
(12): 59-65, 2023.
Artículo
en Chino
| WPRIM
| ID: wpr-971180
ABSTRACT
Chimeric antigen receptor T cell (CAR-T) therapy has shown remarkable success in treating hematological malignancies. However, CAR-T therapy for solid tumors is still limited due to the unique solid-tumor microenvironment and heterogeneous target antigen expression, which leads to an urgent need of combining other therapies. At present, nano delivery system has become one of the most promising directions for the development of anti-tumor drugs. Based on the background of CAR-T and tumor treatment, we focus on the research progress of nanomedicine combined with CAR-T therapy, and systematically review the strategies and examples in recent years in the aspects of in vivo delivery of mRNA, regulation of tumor microenvironment, combination with photothermal therapy. And we also look forward to the future direction of this filed.
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Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Preparaciones Farmacéuticas
/
Linfocitos T
/
Nanopartículas
/
Microambiente Tumoral
/
Receptores Quiméricos de Antígenos
/
Neoplasias Pulmonares
/
Antígenos de Neoplasias
/
Neoplasias
Límite:
Humanos
Idioma:
Chino
Revista:
Chinese Journal of Lung Cancer
Año:
2023
Tipo del documento:
Artículo
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