Glia Connect Inflammation and Neurodegeneration in Multiple Sclerosis / 神经科学通报·英文版
Neuroscience Bulletin
;
(6): 466-478, 2023.
Artículo
en Inglés
| WPRIM
| ID: wpr-971586
ABSTRACT
Multiple sclerosis (MS) is regarded as a chronic inflammatory disease that leads to demyelination and eventually to neurodegeneration. Activation of innate immune cells and other inflammatory cells in the brain and spinal cord of people with MS has been well described. However, with the innovation of technology in glial cell research, we have a deep understanding of the mechanisms of glial cells connecting inflammation and neurodegeneration in MS. In this review, we focus on the role of glial cells, including microglia, astrocytes, and oligodendrocytes, in the pathogenesis of MS. We mainly focus on the connection between glial cells and immune cells in the process of axonal damage and demyelinating neuron loss.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Médula Espinal
/
Encéfalo
/
Neuroglía
/
Inflamación
/
Esclerosis Múltiple
Límite:
Humanos
Idioma:
Inglés
Revista:
Neuroscience Bulletin
Año:
2023
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS