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Seven drimane-type sesquiterpenoids from an earwig-associated Aspergillus sp / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.) ; (6): 58-64, 2023.
Artículo en Inglés | WPRIM | ID: wpr-971664
ABSTRACT
Drimane-type sesquiterpenoids are widely distributed in fungi. From the ethyl acetate extract of the earwig-derived Aspergillus sp. NF2396, seven new drimane-type sesquiterpenoids, named drimanenoids A-G (1-7), were isolated. Their structures were elucidated by diverse spectroscopic analysis including high-resolution ESI-MS, one- and two-dimensional NMR spectroscopy. Drimanenoids A-F (1-6) are new members of drimane-type sesquiterpenoid esterified with unsaturated fatty acid side chain at C-6. Drimanenoids C (3), D (4) and F (6) showed antibacterial activity against five types of bacteria with different inhibition diameters. Drimanenoid D (4) exhibited moderate cytotoxicity against human myelogenous leukemia cell line K562 with an IC50 value of 12.88 ± 0.11 μmol·L-1.
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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Aspergillus / Sesquiterpenos / Espectroscopía de Resonancia Magnética / Estructura Molecular / Sesquiterpenos Policíclicos Límite: Humanos Idioma: Inglés Revista: Chinese Journal of Natural Medicines (English Ed.) Año: 2023 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Aspergillus / Sesquiterpenos / Espectroscopía de Resonancia Magnética / Estructura Molecular / Sesquiterpenos Policíclicos Límite: Humanos Idioma: Inglés Revista: Chinese Journal of Natural Medicines (English Ed.) Año: 2023 Tipo del documento: Artículo