Prenatal Maternal Risk Factors Contributing to Atopic Dermatitis: A Systematic Review and Meta-Analysis of Cohort Studies

ABSTRACT

Background@#The gestational risk factors predispose to the manifestation of early childhood atopic dermatitis (AD). @*Objective@#We evaluated the association between modifiable and non-modifiable gestational and prenatal risk factors that affect the AD prevalence in children. @*Methods@#We performed the systematic review and meta-analysis of cohort studies (n=27) in PubMed and EMBASE (2000~2021). A meta-analysis was performed using random-effects models to estimate pooled odds ratios (OR) or hazard ratio (HR). We performed a systematic review according to Preferred Reporting Item for Systematic Review and Meta-Analyses (PRISMA) guidelines and summarized cohort studies investigating gestational and prenatal risk factor those predispose to AD in off spring. Leading modifiable and non-modifiable were identified through ORs. Meta-analysis using the random effect model was also conducted to provide an overall estimate for several significant factors. @*Results@#Among the non-modifiable risk factors gestational diabetes (7.2, 95% confidence interval [CI] 1.4~34.5), maternal history of allergy (2.14, 95% CI 1.54~2.97) and prenatal history of eczema (2.46, 95% CI 1.0~5.8) were found as major determining risk factors in early manifestation of AD in children. Further, maternal exposure to industrial products (1.89, 95% CI 1.10~3.16), exposure to antibiotics during pregnancy (3.59, 95% CI 1.19~10.85) and passive smoking during pregnancy (2.60, 95% CI 1.11~6.1) are leading causes of early AD manifestation. @*Conclusion@#Conclusively, both genetic and environmental factors play a pivotal role in early manifestation of AD. The better managing the environmental factors during gestational phase to the least can help curtail the prevalence of AD in children.