Optimization of the preparation process of Soft-shelled turtle blood lyophilized powder using Box-Behnken response surface methodology / 中国药房
China Pharmacy
;
(12): 1573-1576, 2023.
Artículo
en Chino
| WPRIM
| ID: wpr-977844
ABSTRACT
OBJECTIVE To optimize the preparation process of Soft-shelled turtle blood lyophilized powder (STBLP), and to provide a reference for improving the availability and quality stability of soft-shelled turtle blood (STB). METHODS STBLP was prepared with vacuum freeze-drying. Taking the solubility as the index, the preparation process parameters of STBLP were optimized by single factor experiment and Box-Behnken response surface method. RESULTS The optimal freeze-drying process for STBLP was obtained: pre-freezing time of 4 h, total drying time of 13 h (before at 0 ℃), and resolution drying temperature of 25 ℃. The average solubility of 3 batches of STBLP prepared according to the optimal process was 95.72% (RSD=0.68%, n=3), the relative error of which was -0.97% to the theoretical solubility (96.66%). CONCLUSIONS Optimized lyophilization process in this study are stable and feasible, the solubility of the prepared sample is high.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
China Pharmacy
Año:
2023
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS