Research progress in pharmacokinetics/pharmacodynamics and drug use of meropenem in special population / 中国药房
China Pharmacy
;
(12): 1661-1664, 2023.
Artículo
en Chino
| WPRIM
| ID: wpr-977861
ABSTRACT
Meropenem is the first choice for the treatment of multi-drug-resistant bacterial infections, which has been widely used in clinical practice. However, the physiological and pathological characteristics of special populations have a significant impact on the pharmacokinetics/pharmacodynamics (PK/PD) parameters of meropenem, so it is necessary to develop individualized drug administration plan according to the characteristics of patients in clinical application. Therefore, this paper summarizes PK/PD characteristics and application of meropenem in special population, and recommends the dosage of meropenem as follows: 10-40 mg/kg, q8 h for children; 1 g, q8-12 h for elderly patients; 0.75 g, q8 h for the patients with renal insufficiency who received continuous veno-venous hemofiltration and continuous veno-venous hemodialysis; 1 g, q8 h prolonged infusion until 3 hours or 2 g, q8 h for patients with hyperrenal function; 1 g, q8 h after 2 g loading dose for patients with cirrhosis.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
China Pharmacy
Año:
2023
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS