Optimization of the extraction process for Xuelian yishen formula by the combination of entropy weight method-analytic hierarchy process with Box-Behnken response surface methodology / 中国药房
China Pharmacy
;
(12): 1858-1862, 2023.
Artículo
en Chino
| WPRIM
| ID: wpr-979937
ABSTRACT
OBJECTIVE To optimize the extraction process of Xuelian yishen formula. METHODS The contents of total flavone, echinacoside and acteoside, and extraction yield in Xuelian yishen formula were chosen as indexes, entropy weight method-analytic hierarchy process was adopted to determine the weight coefficient. Box-Behnken response surface methodology was used to optimize the extraction process of Xuelian yishen formula with extraction time, solid-liquid ratio and extraction times as factors, using comprehensive score of above indexes as index. RESULTS The optimal extraction process of Xuelian yishen formula was extraction time of 2 h, solid-liquid ratio of 1∶12, extracting for 3 times. Average comprehensive score of 3 validation tests was 96.40 points (RSD=0.28%), the deviation of which with predictive value was 0.98%. CONCLUSIONS The optimized extraction process is stable, feasible and reproducible, which can provide reference for the extraction process of Xuelian yishen formula.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
China Pharmacy
Año:
2023
Tipo del documento:
Artículo
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