Scientific basis of acupuncture on mesenchymal stem cells for treating ischemic stroke / 中国针灸
Chinese Acupuncture & Moxibustion
; (12): 691-696, 2023.
Article
en Zh
| WPRIM
| ID: wpr-980780
Biblioteca responsable:
WPRO
ABSTRACT
The scientific basis of acupuncture on mesenchymal stem cells (MSCs) for treating ischemic stroke (IS) is discussed. MSCs transplantation has great potential for the treatment of tissue damage caused by early stage inflammatory cascade reactions of IS, but its actual transformation is limited by various factors. How to improve the homing efficiency of MSCs is the primary issue to enhance its efficacy. As such, the possible mechanisms of acupuncture and MSCs transplantation in inhibiting inflammatory cascade reactions induced by IS are explored by reviewing literature, and a hypothesis that acupuncture could promote the secretion of stromal cell-derived factor-1α (SDF-1α) from ischemic foci to regulate SDF-1α/CXC chemokine receptor 4 (CXCR4) axis, thereby improving the homing efficiency of MSCs transplantation, exerting its neuroprotective function, and improving the bed transformation ability, is proposed.
Palabras clave
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Terapia por Acupuntura
/
Quimiocina CXCL12
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Células Madre Mesenquimatosas
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Accidente Cerebrovascular Isquémico
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Inflamación
Límite:
Humans
Idioma:
Zh
Revista:
Chinese Acupuncture & Moxibustion
Año:
2023
Tipo del documento:
Article