Osteoimmunology research in rheumatoid arthritis: From single-cell omics approach / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 1642-1652, 2023.
Artículo
en Inglés
| WPRIM
| ID: wpr-980931
ABSTRACT
Cellular immune responses as well as generalized and periarticular bone loss are the key pathogenic features of rheumatoid arthritis (RA). Under the pathological conditions of RA, dysregulated inflammation and immune processes tightly interact with skeletal system, resulting in pathological bone damage via inhibition of bone formation or induction of bone resorption. Single-cell omics technologies are revolutionary tools in the field of modern biological research.They enable the display of the state and function of cells in various environments from a single-cell resolution, thus making it conducive to identify the dysregulated molecular mechanisms of bone destruction in RA as well as the discovery of potential therapeutic targets and biomarkers. Here, we summarize the latest findings of single-cell omics technologies in osteoimmunology research in RA. These results suggest that single-cell omics have made significant contributions to transcriptomics and dynamics of specific cells involved in bone remodeling, providing a new direction for our understanding of cellular heterogeneity in the study of osteoimmunology in RA.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Osteoclastos
/
Artritis Reumatoide
/
Huesos
/
Resorción Ósea
/
Inflamación
Límite:
Humanos
Idioma:
Inglés
Revista:
Chinese Medical Journal
Año:
2023
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS