Research progress on the role and clinical significance of DNA methylation in early nutritional programming / 生理学报
Acta Physiologica Sinica
;
(6): 403-412, 2023.
Artículo
en Chino
| WPRIM
| ID: wpr-981016
ABSTRACT
Early life nutritional environment is not only associated with the growth and development of children, but also affects the health of adults. Numerous epidemiological and animal studies suggest that early nutritional programming is an important physiological and pathological mechanism. DNA methylation is one of the important mechanisms of nutritional programming, which is catalyzed by DNA methyltransferase, a specific base of DNA covalently binds to a methyl group, to regulate gene expression. In this review, we summarize the role of DNA methylation in the "abnormal developmental planning" of key metabolic organs caused by excessive nutrition in early life, resulting in long-term obesity and metabolic disorders in the offspring, and explore the clinical significance of regulating DNA methylation levels through dietary interventions to prevent or reverse the occurrence of metabolic disorders in the early stage in a "deprogramming" manner.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Metilación de ADN
/
Fenómenos Fisiologicos Nutricionales Maternos
/
Epigénesis Genética
/
Relevancia Clínica
/
Enfermedades Metabólicas
Límite:
Animales
/
Femenino
/
Humanos
Idioma:
Chino
Revista:
Acta Physiologica Sinica
Año:
2023
Tipo del documento:
Artículo
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