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Advances in Modeling of Multiple Myeloma in Mice / 中国医学科学院学报
Acta Academiae Medicinae Sinicae ; (6): 512-518, 2023.
Artículo en Chino | WPRIM | ID: wpr-981299
ABSTRACT
Multiple myeloma(MM)is a systemic malignancy of plasma cells.Nowadays,the basic research on MM is flourishing with the continuous optimization and innovation of mouse models of MM.Heterologous mouse models of MM established with human-derived cells and immunodeficient mice have been applied in assessing drug efficacy,exploring drug resistance mechanisms,and observing tumor-bone marrow microenvironment interactions.In the last decades,the homologous mouse models of MM established with murine-derived cells or gene-editing technologies have been widely used in the research on the pathogenesis and drug development.Additionally,the stable modeling of targeted organ injury will be a key problem to be tackled in this field.This review summarizes the characteristics and application progress of mouse models of MM.
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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Médula Ósea / Resistencia a Medicamentos / Modelos Animales de Enfermedad / Microambiente Tumoral / Mieloma Múltiple Límite: Animales / Humanos Idioma: Chino Revista: Acta Academiae Medicinae Sinicae Año: 2023 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Médula Ósea / Resistencia a Medicamentos / Modelos Animales de Enfermedad / Microambiente Tumoral / Mieloma Múltiple Límite: Animales / Humanos Idioma: Chino Revista: Acta Academiae Medicinae Sinicae Año: 2023 Tipo del documento: Artículo