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Role of Interleukin-36 in inflammatory joint diseases / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences ; (6): 249-259, 2023.
Artículo en Inglés | WPRIM | ID: wpr-982042
ABSTRACT
Interleukin (IL)-36 is a family of cytokines that belongs to the larger IL-1 superfamily. IL-36 agonist/antagonist binds to the interleukin-36 receptor involving in physiological inflammation regulation and pathogenesis of many inflammatory diseases. In inflammatory joint diseases, the expression of IL-36 changes, and some studies have initially explored the role of IL-36 in these diseases. In psoriatic arthritis, IL-36 signal mediates plasma cell and fibroblast-like synoviocyte crosstalk presenting IL-36 agonist/antagonist imbalance. In rheumatoid arthritis, IL-36 agonists induce fibroblast-like synoviocyte to produce pro-inflammatory factors, while IL-36 antagonist deficiency leads to lesion progression. In osteoarthritis, IL-36 agonists induce chondrocytes to produce catabolic enzymes and pro-inflammatory factors. This article reviews the expression and function of IL-36 in different inflammatory joint diseases to provide a reference for revealing their pathogenic mechanisms and discovering therapeutic targets.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Osteoartritis / Artritis Reumatoide / Artritis Psoriásica / Citocinas / Interleucinas Límite: Humanos Idioma: Inglés Revista: Journal of Zhejiang University. Medical sciences Año: 2023 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Osteoartritis / Artritis Reumatoide / Artritis Psoriásica / Citocinas / Interleucinas Límite: Humanos Idioma: Inglés Revista: Journal of Zhejiang University. Medical sciences Año: 2023 Tipo del documento: Artículo