Progress in the Study of Spindle Assembly Checkpoint in Lung Cancer / 中国肺癌杂志
Chinese Journal of Lung Cancer
;
(12): 310-318, 2023.
Artículo
en Chino
| WPRIM
| ID: wpr-982161
ABSTRACT
Spindle assembly checkpoint (SAC) is a protective mechanism for cells to undergo accurate mitosis. SAC prevented chromosome segregation when kinetochores were not, or incorrectly attached to microtubules in the anaphase of mitosis, thus avoiding aneuploid chromosomes in daughter cells. Aneuploidy and altered expression of SAC component proteins are common in different cancers, including lung cancer. Therefore, SAC is a potential new target for lung cancer therapy. Five small molecule inhibitors of monopolar spindle 1 (MPS1), an upstream component protein of SAC, have entered clinical trials. This article introduces the biological functions of SAC, summarizes the abnormal expression of SAC component proteins in various cancers and the research progress of MPS1 inhibitors, and expects to provide a reference for the future development of lung cancer therapeutic strategies targeting SAC components.
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Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Proteínas Serina-Treonina Quinasas
/
Proteínas de Ciclo Celular
/
Puntos de Control de la Fase M del Ciclo Celular
/
Neoplasias Pulmonares
/
Huso Acromático
Límite:
Humanos
Idioma:
Chino
Revista:
Chinese Journal of Lung Cancer
Año:
2023
Tipo del documento:
Artículo
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