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Investigation of the Correlation between Seoul Neuropsychological Screening Battery Scores and the Gray Matter Volume after Correction of Covariates of the Age, Gender, and Genotypes in Patients with AD and MCI
Journal of the Korean Society of Magnetic Resonance in Medicine ; : 294-307, 2013.
Artículo en Coreano | WPRIM | ID: wpr-98237
ABSTRACT

PURPOSE:

To investigate the correlations between Seoul Neuropsychological Screening Battery (SNSB) scores and the gray matter volumes (GMV) in patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI) and cognitively normal (CN) elderly subjects with correcting the genotypes. MATERIALS AND

METHODS:

Total 75 subjects were enrolled with 25 subjects for each group. The apolipoprotein E (APOE) epsilon genotypes, SNSB scores, and the 3D T1-weighted images were obtained from all subjects. Correlations between SNSB scores and GMV were investigated with the multiple regression method for each subject group using both voxel-based and region-of-interest-based analyses with covariates of age, gender, and the genotype.

RESULTS:

In the AD group, Rey Complex Figure Test (RCFT) delayed recall scores were positively correlated with GMV. In the MCI group, Seoul Verbal Learning Test (SVLT) scores were positively correlated with GMV. In the CN group, GMV negatively correlated with Boston Naming Test (K-BNT) scores and Mini-Mental State Examimation (K-MMSE) scores, but positively correlated with RCFT scores.

CONCLUSION:

When we used covariates of age, gender, and the genotype, we found statistically significant correlations between some SNSB scores and GMV at some brain regions. It may be necessary to further investigate a longitudinal study to understand the correlation.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Apolipoproteínas / Aprendizaje Verbal / Encéfalo / Tamizaje Masivo / Enfermedad de Alzheimer / Disfunción Cognitiva / Seúl / Genotipo / Métodos Tipo de estudio: Estudio diagnóstico / Estudio observacional / Estudio de tamizaje Límite: Anciano / Humanos País/Región como asunto: Asia Idioma: Coreano Revista: Journal of the Korean Society of Magnetic Resonance in Medicine Año: 2013 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Apolipoproteínas / Aprendizaje Verbal / Encéfalo / Tamizaje Masivo / Enfermedad de Alzheimer / Disfunción Cognitiva / Seúl / Genotipo / Métodos Tipo de estudio: Estudio diagnóstico / Estudio observacional / Estudio de tamizaje Límite: Anciano / Humanos País/Región como asunto: Asia Idioma: Coreano Revista: Journal of the Korean Society of Magnetic Resonance in Medicine Año: 2013 Tipo del documento: Artículo