C/EBPβ/AEP Signaling Drives Alzheimer's Disease Pathogenesis / 神经科学通报·英文版
Neuroscience Bulletin
;
(6): 1173-1185, 2023.
Artículo
en Inglés
| WPRIM
| ID: wpr-982455
ABSTRACT
Alzheimer's disease (AD) is the most common type of dementia. Almost two-thirds of patients with AD are female. The reason for the higher susceptibility to AD onset in women is unclear. However, hormone changes during the menopausal transition are known to be associated with AD. Most recently, we reported that follicle-stimulating hormone (FSH) promotes AD pathology and enhances cognitive dysfunctions via activating the CCAAT-enhancer-binding protein (C/EBPβ)/asparagine endopeptidase (AEP) pathway. This review summarizes our current understanding of the crucial role of the C/EBPβ/AEP pathway in driving AD pathogenesis by cleaving multiple critical AD players, including APP and Tau, explaining the roles and the mechanisms of FSH in increasing the susceptibility to AD in postmenopausal females. The FSH-C/EBPβ/AEP pathway may serve as a novel therapeutic target for the treatment of AD.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Transducción de Señal
/
Proteína beta Potenciadora de Unión a CCAAT
/
Enfermedad de Alzheimer
/
Disfunción Cognitiva
/
Hormona Folículo Estimulante
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Neuroscience Bulletin
Año:
2023
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS