Single-cell transcriptomic atlas of mouse cochlear aging
Protein & Cell
;
(12): 180-201, 2023.
Artículo
en Inglés
| WPRIM
| ID: wpr-982532
ABSTRACT
Progressive functional deterioration in the cochlea is associated with age-related hearing loss (ARHL). However, the cellular and molecular basis underlying cochlear aging remains largely unknown. Here, we established a dynamic single-cell transcriptomic landscape of mouse cochlear aging, in which we characterized aging-associated transcriptomic changes in 27 different cochlear cell types across five different time points. Overall, our analysis pinpoints loss of proteostasis and elevated apoptosis as the hallmark features of cochlear aging, highlights unexpected age-related transcriptional fluctuations in intermediate cells localized in the stria vascularis (SV) and demonstrates that upregulation of endoplasmic reticulum (ER) chaperon protein HSP90AA1 mitigates ER stress-induced damages associated with aging. Our work suggests that targeting unfolded protein response pathways may help alleviate aging-related SV atrophy and hence delay the progression of ARHL.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Presbiacusia
/
Estría Vascular
/
Envejecimiento
/
Cóclea
/
Transcriptoma
Límite:
Animales
Idioma:
Inglés
Revista:
Protein & Cell
Año:
2023
Tipo del documento:
Artículo
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