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Applications of DNA methylation markers in forensic medicine / 法医学杂志
Journal of Forensic Medicine ; (6): 61-64, 2005.
Artículo en Chino | WPRIM | ID: wpr-983073
ABSTRACT
DNA methylation is a post-replication modification that is predominantly found in cytosines of the dinucleotide sequence CpG. Epigenetic information is stored in the distribution of the modified base 5-methylcytosine. DNA methylation profiles represent a more chemically and biologically stable source of molecular diagnostic information than RNA or most proteins. Recent advances attest to the great promise of DNA methylation markers as powerful future tools in the clinic. In the past decade, DNA methylation analysis has been revolutionized by two technological advances--bisulphite modification of DNA and methylation-specific polymerase chain reaction (MSP). The methylation pattern of human genome is space-time specific, sex-specific, parent-of-origin specific and disease specific, providing us an alternative way to solve forensic problems.
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Paternidad / ADN / Secuencia de Bases / Marcadores Genéticos / Genoma Humano / Reacción en Cadena de la Polimerasa / Dermatoglifia del ADN / Islas de CpG / Metilación de ADN / Epigénesis Genética Límite: Humanos Idioma: Chino Revista: Journal of Forensic Medicine Año: 2005 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Paternidad / ADN / Secuencia de Bases / Marcadores Genéticos / Genoma Humano / Reacción en Cadena de la Polimerasa / Dermatoglifia del ADN / Islas de CpG / Metilación de ADN / Epigénesis Genética Límite: Humanos Idioma: Chino Revista: Journal of Forensic Medicine Año: 2005 Tipo del documento: Artículo