Experimental pathological study of acute intoxication by Chloranthus serratus Roem. Et Schalt / 法医学杂志
Journal of Forensic Medicine
;
(6): 15-17, 2006.
Artículo
en Chino
| WPRIM
| ID: wpr-983119
ABSTRACT
OBJECTIVE@#To find out the pathological change and the toxic mechanism of Chloranthus serratus Roem. et Schalt in mice.@*METHODS@#Mice were intoxicated by oral administration with extracts of Chloranthus serratus Roem. et Schalt followed by pathological, serum biochemical, and coagulation mechanism examination.@*RESULTS@#The LD50 in mice was 41.12 g/kg; All poisoned mice serum BUN and ALT increased markedly; Thrombocyte decreased and coagulation time increased; The organ index of liver, spleen and kidneys increased significantly; The cells of liver, kidney and heart were degeneration and necrosis, There were extensive hyperemia and hemorrhage in many organs.@*CONCLUSION@#The experiment suggests that the target organs were liver, kidney, heart and blood vessels; The toxic mechanism was the damage on the mitochondrional, endoplasmic reticulum and coagulation system.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Mitocondrias Hepáticas
/
Extractos Vegetales
/
Biomarcadores
/
Distribución Aleatoria
/
Magnoliopsida
/
Patologia Forense
/
Relación Dosis-Respuesta a Droga
/
Retículo Endoplásmico
/
Riñón
/
Dosificación Letal Mediana
Límite:
Animales
Idioma:
Chino
Revista:
Journal of Forensic Medicine
Año:
2006
Tipo del documento:
Artículo
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