Forensic pathological significance of immunohistochemical study with CX43 in rats on early myocardial ischaemia / 法医学杂志

ABSTRACT

OBJECTIVE@#To explore one of evidence for pathologic diagnosis of early myocardial ischaemia.@*METHODS@#Rats were ligated of the left coronary artery according to a previously documented technique, and heart tissue was sampled at different ischaemia time. The expression of CX43 in myocardial cell was detected by Immunohistochemistry.@*RESULTS@#It is showed that the distribution and amount of CX43 positive staining in each group of the myocardial ischaemia was different from that of the control group.@*CONCLUSION@#The changes of CX43 detected by Immunohistochemical methods may be helpful for the diagnosis of early myocardial ischaemia, but further pathologic investigation and research is necessary.