Expression of matrix metalloproteinase-3 after brain contusion in rats / 法医学杂志
Journal of Forensic Medicine
;
(6): 1-5, 2009.
Artículo
en Chino
| WPRIM
| ID: wpr-983430
ABSTRACT
OBJECTIVE@#To investigate the expression of matrix metalloproteinase-3 after brain contusion and its applicability for estimating the age of brain contusion.@*METHODS@#Rats had been divided into three groups control group, sham operation group and brain contusion group. The expression of matrix metalloproteinase-3 at different time was detected by immunohistochemistry and Western blot.@*RESULTS@#By the immunohistochemistry, no staining was observed in control and sham operation groups. The positive staining of MMP-3 appeared 6 hours after contusion, increased gradually in 24 hours and peaked 5 days after contusion, then started to decrease, 14 days after contusion still could be observed. By the Western blot analysis, no expression of MMP-3 was detected in control and sham groups. The positive staining of MMP-3 appeared 6 hours after contusion, increased gradually and maximized 5 days after contusion, then started to decrease, 14 days after contusion still could be found.@*CONCLUSION@#Time-order expression of MMP-3 could be used for estimating the age of brain contusion in forensic pathology.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Factores de Tiempo
/
Lesiones Encefálicas
/
Inmunohistoquímica
/
Distribución Aleatoria
/
Western Blotting
/
Ratas Sprague-Dawley
/
Metaloproteinasa 3 de la Matriz
/
Patologia Forense
Límite:
Animales
Idioma:
Chino
Revista:
Journal of Forensic Medicine
Año:
2009
Tipo del documento:
Artículo
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