Behavior study of ketamine-induced symptoms similar to schizophrenia in mice / 法医学杂志
Journal of Forensic Medicine
;
(6): 172-175, 2009.
Artículo
en Chino
| WPRIM
| ID: wpr-983466
ABSTRACT
OBJECTIVE@#To observe the symptoms similar to schizophrenia in mice after ketamine single or continuous injection and to evaluate the feasibility of schizophrenia model injected with different dose of ketamine.@*METHODS@#A total of 40 male mice were randomly divided into 4 groups, which were injected intraperitoneally with physiological saline (control group), 25 mg/kg ketamine (low dose group), 50 mg/kg ketamine (middle dose group), and 100 mg/kg ketamine (high dose group) qd for 7 days continuously. The behavior changes of mice were observed.@*RESULTS@#Hyperactivity, stereotyped behavior and ataxia (P < 0.01) were observed in high dose group after single injection. After continuous injection of ketamine for 7 days, the middle dose group showed hyperactivity, stereotyped behavior and ataxia (P < 0.05), stereotyped behavior and ataxia were more significant in high dose group (P < 0.01).@*CONCLUSION@#Ketamine can induce the symptoms similar to schizophrenia in mice after single or continuous injection. The symptoms induced by high dose ketamine will be more prominent and stable after continuous injection.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Ataxia
/
Esquizofrenia
/
Conducta Estereotipada
/
Psiquiatría Forense
/
Distribución Aleatoria
/
Receptores de N-Metil-D-Aspartato
/
Modelos Animales de Enfermedad
/
Relación Dosis-Respuesta a Droga
/
Inyecciones Intraperitoneales
/
Ketamina
Límite:
Animales
Idioma:
Chino
Revista:
Journal of Forensic Medicine
Año:
2009
Tipo del documento:
Artículo
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