Effect of temperature and time on stability of ketamine in biological samples / 法医学杂志
Journal of Forensic Medicine
;
(6): 434-436, 2009.
Artículo
en Chino
| WPRIM
| ID: wpr-983520
ABSTRACT
OBJECTIVE@#The stability of ketamine in biological samples was studied under different storage temperature and time.@*METHODS@#The rabbits were given intragastric administration of ketamine with a dose of 150 mg/kg and were sacrificed after 30 minutes. Blood, liver, kidney and brain of the rabbits were stored at room temperature (between 18 degrees C and 24 degrees C) and -20 degrees C. The specimens were analyzed at different times by GC-MS and GC-NPD.@*RESULTS@#At -20 degrees C, the concentration of ketamine decreased in all of samples (P < 0.05) within 30 days. The concentration of ketamine increased in all of samples stored at room temperature after 5 days(P < 0.05).@*CONCLUSION@#The stability of ketamine in biological samples stored at -20 degrees C was better than that at room temperature. The samples suspected containing ketamine should be stored at -20 degrees C and should be tested as soon as possible.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Manejo de Especímenes
/
Temperatura
/
Factores de Tiempo
/
Encéfalo
/
Criopreservación
/
Modelos Animales de Enfermedad
/
Estabilidad de Medicamentos
/
Toxicología Forense
/
Concentración de Iones de Hidrógeno
/
Ketamina
Límite:
Animales
Idioma:
Chino
Revista:
Journal of Forensic Medicine
Año:
2009
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS