Screening and confirmation of psychotropic drugs in blood and urine by HPLC-LTQ Orbitrap MS / 法医学杂志
Journal of Forensic Medicine
;
(6): 44-48, 2012.
Artículo
en Chino
| WPRIM
| ID: wpr-983712
ABSTRACT
OBJECTIVE@#To establish a screening and confirmation method for psychotropic drugs and their metabolites in human blood and urine by HPLC-LTQ Orbitrap MS.@*METHODS@#The samples were pretreated with Sirocco protein precipitation plate, and then analyzed by HPLC-LTQ Orbitrap MS. The method was validated in terms of the limit of detection (LOD). An accurate mass database was created for psychotropic drugs screening.@*RESULTS@#The LOD for most of 56 determined compounds was < or = 0.1 ng/mL. The accurate mass database included the accurate mass information of 61 psychotropic drugs.@*CONCLUSION@#The method is accurate, rapid, sensitive and the database is suitable for psychotropic drugs screening and confirmation.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Psicotrópicos
/
Espectrometría de Masas
/
Estructura Molecular
/
Detección de Abuso de Sustancias
/
Reproducibilidad de los Resultados
/
Cromatografía Líquida de Alta Presión
/
Sensibilidad y Especificidad
/
Toxicología Forense
/
Peso Molecular
Límite:
Humanos
Idioma:
Chino
Revista:
Journal of Forensic Medicine
Año:
2012
Tipo del documento:
Artículo
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