Genetic polymorphisms of four SNP loci in D5 gene of dopamine receptor in Northern Chinese Han population / 法医学杂志
Journal of Forensic Medicine
;
(6): 37-48, 2013.
Artículo
en Chino
| WPRIM
| ID: wpr-983791
ABSTRACT
OBJECTIVE@#To reveal the genetic polymorphisms of four SNP loci (rs77434921, rs2076907, rs6283, rs1800762) in D5 gene of dopamine receptor (DRD5) in Northern Chinese Han population.@*METHODS@#Four SNP loci of the DRD5 gene of 206 unrelated individuals in Northern Chinese Han population were separately amplified and sequenced by PCR technique and statistically analyzed by Haploview v4.1 software.@*RESULTS@#In Northern Chinese Han population, the genotype frequency distribution of rs77434921, rs2076907, rs6283 and rs1800762 loci in the DRD5 gene were all in accordance with Hardy-Weinberg equilibrium. DP value was 0.145, 0.532, 0.602 and 0.159, while PE value was 0.004, 0.079, 0.196 and 0.007. A linkage disequilibrium among these four SNP loci was also demonstrated, which might infer five haplotypes.@*CONCLUSION@#rs2076907 and rs6283 loci of DRD5 gene in the Northern Chinese Han population have high genetic polymorphisms, which can be useful for forensic identification of individuals.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Haplotipos
/
Marcadores Genéticos
/
Desequilibrio de Ligamiento
/
China
/
Reacción en Cadena de la Polimerasa
/
Cartilla de ADN
/
Polimorfismo de Nucleótido Simple
/
Pueblo Asiatico
/
Receptores de Dopamina D5
/
Genética Forense
Límite:
Humanos
País/Región como asunto:
Asia
Idioma:
Chino
Revista:
Journal of Forensic Medicine
Año:
2013
Tipo del documento:
Artículo
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