Expression of GAP-43 in midbrain ventral tegmental area of morphine withdrawal rats / 法医学杂志
Journal of Forensic Medicine
;
(6): 330-336, 2013.
Artículo
en Chino
| WPRIM
| ID: wpr-983844
ABSTRACT
OBJECTIVE@#To observe the protein expression of growth associated protein-43 (GAP-43) in midbrain ventral tegmental area in morphine withdrawal rats at different time, and to evaluate the effect of GAP-43 on morphine withdrawal memory.@*METHODS@#Rat models of morphine dependent 1 week, 2 weeks and 4 weeks were established by morphine hydrochloride intraperitoneal injection with increasing doses to establish natural withdrawal. The protein expression of GAP-43 in midbrain ventral tegmental area was observed by immunohistochemical staining and the results were analyzed by Image-Pro Plus 5.1 image analysis system.@*RESULTS@#With prolongation of dependent time, the expression of GAP-43 was decreased then increased in midbrain ventral tegmental area.@*CONCLUSION@#GAP-43 could play a role in morphine withdrawal memory in midbrain ventral tegmental area.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Síndrome de Abstinencia a Sustancias
/
Factores de Tiempo
/
Conducta Animal
/
Mesencéfalo
/
Inmunohistoquímica
/
Ratas Sprague-Dawley
/
Área Tegmental Ventral
/
Proteína GAP-43
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Modelos Animales de Enfermedad
/
Morfina
Límite:
Animales
Idioma:
Chino
Revista:
Journal of Forensic Medicine
Año:
2013
Tipo del documento:
Artículo
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