Gene detection of GPD1-L and the association with sudden unexplained death syndrome in young adults / 法医学杂志
Journal of Forensic Medicine
;
(6): 348-352, 2013.
Artículo
en Chino
| WPRIM
| ID: wpr-983849
ABSTRACT
OBJECTIVE@#To analyze the variations of glycerol-3-phosphate dehydrogenase 1 like gene (GPD1-L) and address the association with sudden manhood death syndrome (SMDS).@*METHODS@#The genomic DNA was extracted from blood samples of the SMDS group and the normal control group. The exons, exon-intron boundaries and 3'-UTRs of coding region of GPD1-L were PCR amplified and DNA sequenced directly to confirm the types of variations. The genotype frequency and allele frequency were analyzed statistically.@*RESULTS@#There were two variants in the SMDS group, c.465C>T and c.*18G>T, the latter existed certain degree difference of genotype distribution and allele frequency between the SMDS group and the control group, but there was no statistically significant (P > 0.05).@*CONCLUSION@#The relation between gene mutation of GPD1-L and the occurrence of Chinese SMDS deserves a further research.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Análisis Mutacional de ADN
/
Secuencia de Bases
/
Estudios de Casos y Controles
/
Reacción en Cadena de la Polimerasa
/
Exones
/
Cartilla de ADN
/
Polimorfismo de Nucleótido Simple
/
Muerte Súbita
/
Pueblo Asiatico
/
Frecuencia de los Genes
Límite:
Adolescente
/
Adulto
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Journal of Forensic Medicine
Año:
2013
Tipo del documento:
Artículo
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