Clinical characteristics of 11 patients with chronic lymphocytic leukemia with t (14;19) (q32;q13) / 中华血液学杂志
Chinese Journal of Hematology
;
(12): 418-423, 2023.
Artículo
en Chino
| WPRIM
| ID: wpr-984639
ABSTRACT
Objective:
To analyze the clinicopathological characteristics of 11 cases of chronic lymphocytic leukemia (CLL) with t (14;19) (q32;q13) .Methods:
The case data of 11 patients with CLL with t (14;19) (q32;q13) in the chromosome karyotype analysis results of the Blood Diseases Hospital, Chinese Academy of Medical Sciences from January 1, 2018, to July 30, 2022, were retrospectively analyzed.Results:
In all 11 patients, t (14;19) (q32;q13) involved IGHBCL3 gene rearrangement, and most of them were accompanied by +12 or complex karyotype. An immunophenotypic score of 4-5 was found in 7 patients and 3 in 4 cases. We demonstrated that CLLs with t (14;19) (q32;q13) had a mutational pattern with recurrent mutations in NOTCH1 (3/7), FBXW7 (3/7), and KMT2D (2/7). The very-high-risk, high-risk, intermediate-risk, and low-risk groups consisted of 1, 1, 6, and 3 cases, respectively. Two patients died, 8 survived, and 2 were lost in follow-up. Four patients had disease progression or relapse during treatment. The median time to the first therapy was 1 month.Conclusion:
t (14;19) (q32;q13), involving IGHBCL3 gene rearrangement, is a rare recurrent cytogenetic abnormality in CLL, which is associated with a poor prognosis.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Translocación Genética
/
Leucemia Linfocítica Crónica de Células B
/
Estudios Retrospectivos
/
Aberraciones Cromosómicas
/
Cariotipificación
Límite:
Humanos
Idioma:
Chino
Revista:
Chinese Journal of Hematology
Año:
2023
Tipo del documento:
Artículo
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