Research Progress on Gene Alterations of Amelogenin Locus in Gender Identification / 法医学杂志
Journal of Forensic Medicine
;
(6): 371-377, 2016.
Artículo
en Chino
| WPRIM
| ID: wpr-984864
ABSTRACT
There are two kinds of amelogenin gene mutation, including mutation in primer-binding region of amelogenin gene and micro deletion of Y chromosome encompassing amelogenin gene, and the latter is more common. The mechanisms of mutation in primer-binding region of amelogenin gene is nucleotide point mutation and the mechanism of micro deletion of Y chromosome encompassing amelogenin gene maybe non-allelic homologous recombination or non-homologous end-joining. Among the population worldwide, there is a notably higher frequency of amelogenin gene mutations in Indian population, Sri Lanka population and Nepalese population which reside within the Indian subcontinent. Though amelogenin gene mutations have little impact on fertility and phenotype, they might cause incorrect result in gender identification. Using composite-amplification kit which including autosomal STR locus, amelogenin gene locus and multiple Y-STR locus, could avoid wrong gender identification caused by amelogenin gene mutation.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Sri Lanka
/
Reacción en Cadena de la Polimerasa
/
Aberraciones Cromosómicas
/
Eliminación de Secuencia
/
Repeticiones de Microsatélite
/
Cromosomas Humanos Y
/
Pueblo Asiatico
/
Alelos
/
Amelogenina
/
India
Límite:
Humanos
/
Masculino
País/Región como asunto:
Asia
Idioma:
Chino
Revista:
Journal of Forensic Medicine
Año:
2016
Tipo del documento:
Artículo
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