Research Progress on the Detection Method of DNA Methylation and Its Application in Forensic Science / 法医学杂志
Journal of Forensic Medicine
;
(6): 293-300, 2017.
Artículo
en Chino
| WPRIM
| ID: wpr-984896
ABSTRACT
As an important part of epigenetic marker, DNA methylation involves in the gene regulation and attracts a wide spread attention in biological auxology, geratology and oncology fields. In forensic science, because of the relative stable, heritable, abundant, and age-related characteristics, DNA methylation is considered to be a useful complement to the classic genetic markers for age-prediction, tissue-identification, and monozygotic twins' discrimination. Various methods for DNA methylation detection have been validated based on methylation sensitive restriction endonuclease, bisulfite modification and methylation-CpG binding protein. In recent years, it is reported that the third generation sequencing method can be used to detect DNA methylation. This paper aims to make a review on the detection method of DNA methylation and its applications in forensic science.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Sulfitos
/
Gemelos Monocigóticos
/
Marcadores Genéticos
/
Islas de CpG
/
Metilación de ADN
/
Epigénesis Genética
/
Genética Forense
/
Epigenómica
Límite:
Humanos
Idioma:
Chino
Revista:
Journal of Forensic Medicine
Año:
2017
Tipo del documento:
Artículo
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