Rapid Identification of Four New Synthetic Cannabinoids in Whole Blood / 法医学杂志
Journal of Forensic Medicine
;
(6): 677-681, 2019.
Artículo
en Inglés
| WPRIM
| ID: wpr-985062
ABSTRACT
Objective To establish accurate and rapid methods to identify four new synthetic cannabinoids (JWH-203, JWH-122, 5F-APINACA and AB-CHMINACA) in blood samples. Methods The whole blood samples were extracted by acetonitrile and methanol, screened by gas chromatography-mass spectrometry (GC-MS) then confirmed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) method, and multiple reaction monitoring (MRM) mode was used for quantitative analysis. Results The GC-MS method needed 21 min to complete the analysis, while the LC-MS/MS method needed 5 min. The AB-CHMINACA, JWH-203, 5F-APINACA and JWH-122 all used quasi molecular ion peak as a parent ion. The precursor-product ion combinations were m/z 357.4→312.2, m/z 340.2→125.0, m/z 384.1→135.1 and m/z 356.4→169.2. The four synthetic cannabinoids in blood samples had good linearity in the 1-250 ng/mL mass concentration range (r>0.99). The limits of detection (LODs) were in the range of 0.1-0.5 ng/mL, the recovery rate was 85.4%-95.2%, the RSD less than 10.0%, and the matrix effect was 80.3%-92.8%. Conclusion The GC-MS and LC-MS/MS chromatographic behaviors and mass spectrometry analysis information of four synthetic cannabinoids were obtained in this study, and the possible causes of differences in chromatographic behaviors were discussed preliminarily. Therefore this study has a suggestive effect on judging the development trend of synthetic cannabinoids. This method can be used for rapid identification of four synthetic cannabinoids in blood, which can provide reference for identification of new synthetic cannabinoids when they are proliferating at present.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Análisis Químico de la Sangre
/
Cannabinoides
/
Detección de Abuso de Sustancias
/
Cromatografía Liquida
/
Espectrometría de Masas en Tándem
/
Límite de Detección
Límite:
Humanos
Idioma:
Inglés
Revista:
Journal of Forensic Medicine
Año:
2019
Tipo del documento:
Artículo
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