A conceptual framework for dynamics of cccDNA in hepatitis B virus / 中华肝脏病杂志
Chinese Journal of Hepatology
;
(12): 545-550, 2023.
Artículo
en Chino
| WPRIM
| ID: wpr-986167
ABSTRACT
The resolution of the hepatitis C issue has raised expectations for a chronic hepatitis B cure, driving the industry to expand investment in research and development efforts to strengthen functional cure strategies. These strategies have a wide variety of types, and the published research findings are heterogeneous. The theoretical analysis of these strategies is of great significance for determining prioritized research orientations as well as sensibly allocating research and development resources. However, due to a paucity of necessary conceptual models, current theoretical analysis has not been able to unify various therapeutic strategies into a proper theoretical framework. In view of the fact that the decrease in the quantity of cccDNA is an inevitable core event accompanied by the process of functional cure, this paper intends to analyze several chronic hepatitis B cure strategies using cccDNA dynamics as a framework. Furthermore, there are currently few studies on the dynamics of the cccDNA field, hoping that this article can promote recognition and research in this field.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Antivirales
/
Replicación Viral
/
ADN Circular
/
ADN Viral
/
Virus de la Hepatitis B
/
Hepatitis B Crónica
/
Hepatitis B
Límite:
Humanos
Idioma:
Chino
Revista:
Chinese Journal of Hepatology
Año:
2023
Tipo del documento:
Artículo
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